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Antibody Evolution Constrains Conformational Heterogeneity by Tailoring Protein Dynamics
flexibility nonlinear spectroscopy fluorscein molecular recognition
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2016/5/24
The evolution of proteins with novel function is thought to start from precursor proteins that are conformationally heterogeneous. The corresponding genes may be duplicated and then mutated to select ...
Reaction Event Counting Statistics of Biopolymer Reaction Systems with Dynamic Heterogeneity
Reaction Event Counting Statistics Biopolymer Reaction Systems Dynamic Heterogeneity
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2014/9/24
We investigate the reaction event counting statistics (RECS) of an elementary biopolymer reaction in which the rate coefficient is dependent on states of the biopolymer and the surrounding environment...